不同体力活动水平高校女性教师递增负荷运动前后血清心肌酶的比较研究     

赖晓红  曹建民  黄剑雅 《广州体育学院学报》2014,(5):94-98

目的:研究不同体力活动水平女性教师递增负荷前后血清心肌酶的差异,进而评估不同体力活动水平女性教师运动中可能出现的心脏风险。方法:对受试者进行体力活动问卷调查,从中筛选87名健康女性教师进行递增负荷试验,测试运动测试前后的心肌酶指标进行比较分析。结果:1)运动前安静状态下,体力活动不足组心肌酶各指标值均低于中、高水平体力活动组,其中体力活动不足组CK-MB显著的低于中等组(P0.05)并且非常显著的低于高等组(P0.01)。2)运动测试后,体力活动高水平组CK值显著的高于体力活动不足组(P0.05),除AST以外,其余心肌酶水平随着体力活动水平的升高而升高。其中体力活动不足组AST值超过正常值范围,提示心肌组织出现了一定的损伤。3)除中等和高水平体力活动组的CK-MB运动后比运动前有所下降外,其余各组指标运动后都有所升高,特别是三组的CK、AST都非常显著的升高(P0.01),从运动前后差值比较分析来看,不足组的CK、AST增加值显著的高于中等组和高等组(P0.05)。结论:1.体力活动不足的高校女性教师安静状态下的心肌酶水平较低。2.递增负荷运动会引起高校女性教师心肌细胞出现一定程度的损伤,运动后血清心肌酶水平有所升高,而且体力活动不足女性的损伤更为严重,主要表现在心肌酶指标中的CK和AST。  相似文献   

心肌桥与运动员选材     

胡柏平  刘旭娇 《山西师大体育学院学报》2014,(4):110-113

通过阐释心肌桥的形态结构和运动员心脏的特点,分析了心肌桥可能引起急性冠脉综合症、严重的心律失常甚至猝死。尤其是在运动情况下,心肌缺氧缺血等情况会较为明显。而心律失常在长期从事严格运动训练的运动员中时有发生。研究认为,在运动员选材中应将心肌桥的检查作为一项重要指标,对运动员选材的成功率有一定的帮助。  相似文献   

血管紧张素转化酶基因I/D多态性与高血压脑梗塞发病的相关性   总被引：2，自引：0，他引：2  

杜明艳  封靖  周桔  丁文军 《中国科学院研究生院学报》2010,27(6):778-781

采用PCR方法分别检测82例高血压合并脑梗塞患者(BI)、67例单纯高血压患者(EH)和95例健康对照者(C)的血管紧张素转化酶(ACE)基因I/D多态性类型,并分析ACE基因I/D多态性分布与高血压合并脑梗塞发病的相关性.结果显示,BI组ACE基因的D/D基因型频率和D等位基因频率(分别为0.341和0.524)显著高于C组(分别为0.200和0.374,P<0.05)和EH组(分别为0.179和0.358,P<0.05),而EH组和C组ACE基因的D/D基因型频率和D等位基因频率无显著性差异.该研究结果表明,ACE基因的D/D基因型可能是高血压合并脑梗塞发病的独立危险因素.  相似文献   

Renal insufficiency is an independent predictor of in-hospital mortality for patients with acute myocardial infarction receiving primary percutaneous coronary intervention     

Mohetaboer MOMIN 《Journal of Zhejiang University. Science. B》2012,13(8):638-644

Objective:To investigate the relationship between renal function and clinical outcomes among patients with acute ST-segment elevation myocardial infarction (ASTEMI), who were treated with emergency percutaneous coronary intervention (PCI). Methods: 420 patients hospitalized in Peking University First Hospital, diagnosed with ASTEMI treated with emergency (PCI) from January 2001 to June 2011 were enrolled in this study. Estimated glomerular filtration rate (eGFR) was used as a measure of renal function. We compared the clinical parameters and outcomes between ASTEMI patients combined renal insufficiency and the patients with normal renal function. Results:There was a significant increase in the concentrations of fibrinogen and D-Dimer (P<0.05) and a much higher morbidity of diabetes mellitus in the group of patients with chronic kidney disease (CKD; eGFR<60 ml/(min·1.73 m2)) (P<0.01). CKD (eGFR<60 ml/(min·1.73 m2)) was an independent predictor of in-hospital mortality for patients hospitalized with ASTEMI receiving PCI therapy rapidly (P=0.032, odds ratio (OR) 4.159, 95% confidence interval (CI) 1.127-15.346). Conclusions:Renal insufficiency is an independent predictor of in-hospital mortality for patients hospitalized with ASTEMI treated with primary PCI.  相似文献   

Glycogen phosphorylase isoenzyme BB in the diagnosis of acute myocardial infarction: a meta-analysis     

Giuseppe Lippi  Camilla Mattiuzzi  Ivan Comelli  Gianfranco Cervellin 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2013,23(1):78-82

Background

Early diagnosis is crucial for management of patients with suspected acute myocardial infarction (AMI). Among innovative and promising biomarkers, the recent interest raised on glycogen phosphorylase isoenzyme BB (GPBB) has prompted us to perform a meta-analysis of published studies.

Materials and methods:

A systematic electronic search was carried out on PubMed, Web of Science and Google Scholar, with no date restriction, to retrieve all articles that have investigated the early diagnostic performance of GPBB in patients with suspected AMI, and directly reported or allowed calculation of sensitivity and specificity. A meta-analysis of the reported sensitivity and specificity of each study and pooled area under the curve (AUC) was then performed by random effect approach. Heterogeneity was assessed by I-square statistics.

Results:

Eight studies were finally selected for analysis (941 subjects; 506 cases and 435 controls), with a high heterogeneity (I-squared, 86.3%). The resulting pooled estimates and 95% confidence interval were 0.854 (0.801–0.891) for sensitivity, 0.767 (0.713–0.815) for specificity, 0.826 (0.774–0.870) for negative predictive value, 0.802 (0.754–0.844) for positive predictive value, and 0.754 (0.602–0.907) for AUC. In those studies that have simultaneously assessed GPBB and a troponin immunoassay, the combination of these biomarkers did not significantly improve the performance of troponin alone.

Conclusion:

GPBB does not meet the current requirements for an efficient diagnosis of AMI when used as a stand-alone test, whereas its combination with troponin merits further investigation in larger trials.  相似文献   

Serum Paraoxonase (PON1) Activity in North-West Indian Punjabi’s with Acute Myocardial Infarction     

V. Nagarjuna Maturu  Nidhi Gupta  Gagandip Singh  Kirandip Gill  Yash Paul Sharma  Surjit Singh 《Indian journal of clinical biochemistry : IJCB》2013,28(3):248-254

Human serum paraoxonase-1 (PON1), an enzyme on HDL prevents oxidation of LDL thereby preventing the development of atherosclerosis. Studies done so far have lead to conflicting results. As studies are lacking in North-West Indian Punjabi’s, a distinct ethnic group with high incidence of coronary artery disease, we determined PONase activity in this population. It has been postulated that sudden lowering of serum PONase may lead to precipitation of acute myocardial infarction. We determined serum PONase activity and lipids in 100 patients each of AMI (within 24 h of onset), stable CAD and 100 age and sex matched healthy controls. These were again determined after 6 weeks in AMI patients. The mean serum PONase activity was lowest in AMI patients (23.26 U/ml) followed by stable CAD patients (102.0 U/ml) where as in controls was highest (179.8 U/ml). In patients with AMI, activity was significantly higher at 6 weeks as compared to that after acute event (49.39 %; p < 0.05). Sudden lowering of serum PONase activity in a population which already has lower activity may be one of the risk factors for development of AMI.  相似文献   

Respiratory face mask: a novel and cost-effective device for use during the application of myocardial ischemia in rats     

Yuan Yuan  Fei Li  Yue-min Wang  Rong-qing Zhang  Li-ping Wei  Hai-chang Wang 《Journal of Zhejiang University. Science. B》2009,10(5):391-394

To shorten operation time and improve survival rate of rats with myocardial ischemia or myocardial infarction, we use a novel device comprised of a face mask and a head/neck retainer in this study. We report the basic design of the novel respiratory face mask (RFM) and evaluate its performance in a rat model of myocardial ischemia. The device is cost-effective and easier to handle than other devices, such as tracheal intubation. Compared with conventional tracheal intubation, we found that RFM shortens operation time significantly while keeping blood indices normal; the mean operation time for rats in the mask group was (32±3) min, and that for the intubation group was (45±7) min (P<0.05). Moreover, the size and shape of the RFM can be changed according to the body weight of rats. In conclusion, RFM is an appropriate device for the establishment of myocardial infarction or ischemia-reperfusion in rats.  相似文献   

穴位埋线对冠心病无症状心肌缺血、心肌缺血总负荷的影响     

刘卫平  邢之华  林展增  吴建琼 《河北北方学院学报(医学版)》2002,19(6):27-28

目的 :研究穴位埋线对无症状心肌缺血动态心电图的影响。方法 :以随机对照方法 ,观察治疗组 (穴位埋线 )和对照组 (普奈洛尔组 )对无症状心肌缺血的影响。结果 :两组治疗前后 ,在心肌缺血次数 ,心肌缺血持续时间 ,以及缺血总负荷方面有明显差异 ,P <0 .0 1,与对照组治疗后相比 ,无明显差异 ,P >0 .0 5。结论 :穴位埋线在改善无症状心肌缺血方面具肯定疗效。  相似文献   

黄芪配伍川芎嗪抗心肌缺血再灌注损伤的研究     

宋丽华  汤碧娥  张宁  陈晓明 《金华职业技术学院学报》2007,7(6):45-48

目的:观察黄芪注射液配伍川芎嗪对家兔心肌缺血再灌注损伤的保护作用。方法:采用在体家兔冠状动脉阻断的缺血/复灌损伤模型,测定心肌梗死面积、血浆中乳酸脱氢酶(LDH)和肌酸激酶(CK)活性及各项心室力学指标。结果:与单纯缺血/复灌组相比,川芎嗪与黄芪两药明显降低心脏缺血/复灌后的梗死面积和血浆中LDH、CK含量,促进左室收缩压(LVSP)、最大左室收缩速率( dP/dtmax)和最大左室舒张速率(-dP/dtmax)的恢复,两药合用与单用比较各项指标的恢复更加显著。结论:黄芪与川芎嗪两药合用在保护心肌缺血再灌注损伤中有显著的协同作用。  相似文献   

β-受体阻断剂对心脏康复跑台运动时机能、生理、临床和感觉反应的影响     

刘洵  Brodie D A  任丽伟  Bundred P E 《体育科学》2006,26(9):28-30,33

目的：测试服用和未服用β-受体阻断剂的心梗后患者（PMIP）在跑台运动中其功能、生理、临床及自我感觉方面的反应。方法：46名服用β-受体阻断剂的男性PMIP和55名未服用β-受体阻断剂的男性PMIP进行递增负荷运动实验，其间记录每级负荷时的摄氧量（VO2）、心率（HR）、血压和自我用力感觉（RPE），并持续监测12导联心电图（ECG）。结果：服用β-受体阻断荆的患者其安静时和运动中的HR、最大心率百分比（％HRmax）及心率血压乘积（RPP）显著低于未服用β-受体阻断剂的患者（P〈0．01）。运动中，服用β-受体阻断剂的患者有59％能够完成改良布鲁斯跑台方案的第Ⅳ级运动，而在未服用β-受体阻断剂的患者中仅有49％能完成这一负荷。两组在运动中各级别VO2、RPE及ST段下移无显著性差异。结论：由β受体阻断剂所致的HR降低并没有直接地影响到氧利用和代谢机能。  相似文献